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Located on Via Cola di Rienzo, the hotel is situated in the elegant Prati district, home to the Vatican and Saint Peter's Basilica. Vatican City can be reached in around 15 minutes on foot and Piazza del Popolo and Piazza di Spagna are also within walking distance. The metro station Lepanto is only 500 m from the hotel. Ciampino Airport is approximately 15 km away and Leonardo da Vinci – Fiumicino Airport is about 28 km away.

Via Cola di Rienzo 23
Check-in from 3:00 PM · Check-out by 11:00 AM

Via Cola di Rienzo 23
Check-in from 3:00 PM · Check-out by 11:00 AM
Very Good
2042 reviewsUser: Diana S
Trip type: Family
Don't book this hotel- We had a pest issue at our room!!
My family and I stayed last wee in this hotel. Right after we went to bed, tick Bugs started coming out of my 3 year old's bed. If bitten, these Bugs can pose serious health risks especially to a little chile. After calling Management, they committed to support any claim Made through our Booking channel. However, they denied any responsibility and failed to reach to a settlement. Not only do they… My family and I stayed last wee in this hotel. Right after we went to bed, tick Bugs started coming out of my 3 year old's bed. If bitten, these Bugs can pose serious health risks especially to a little chile. After calling Management, they committed to suppor…
User: Mcggncm
Trip type: Family
Do not stay here unless you like a very hard mattress.
I am currently on night one of a two night stay and I can tell you, the beds are the most uncomfortable mattresses I have ever felt and I travel a fair amount.I'm not sure I'll be able to walk tomorrow. Other than that, rooms are decent and clean. Federico Bosi, Direttore generale at Hotel Twenty One, responded to this review Dear Guest,Thank you for sharing your feedback. We are sorry to hea… I am currently on night one of a two night stay and I can tell you, the beds are the most uncomfortable mattresses I have ever felt and I travel a fair amount.I'm not sure I'll be able to walk tomorrow. Other than that, rooms are decent and clean. Federico…
User: 1Tag
Trip type: Couples
Lovely hotel
We came to Rome for our 40 wedding anniversary. I chose Hotel 21. It did not disappoint. Friendly staff, from receptionist, cleaner, to waiting on staff.Breakfast was lovely. From continental, to English. Eggs, bacon, toast, cakes, cereals. Even fresh pancakes.Air con through out, which was a god send when it’s 40 outside.We would highly recommend this hotel. Federico Bosi, Direttore generale a… We came to Rome for our 40 wedding anniversary. I chose Hotel 21. It did not disappoint. Friendly staff, from receptionist, cleaner, to waiting on staff.Breakfast was lovely. From continental, to English. Eggs, bacon, toast, cakes, cereals. Even fresh pancakes…
User: Paul J
Trip type: Couples
Great place to stay in Rome
Great hotel, b very convenient for Rome. Lovely staff, very good breakfast and comfortable and clean rooms Federico Bosi, Direttore generale at Hotel Twenty One, responded to this review Dear Maxime,Thank you so much for taking the time to share such a lovely review of your stay with us!We are absolutely thrilled to hear that you had a great experience and found our hotel to be very convenien… Great hotel, b very convenient for Rome. Lovely staff, very good breakfast and comfortable and clean rooms Federico Bosi, Direttore generale at Hotel Twenty One, responded to this review Dear Maxime,Thank you so much for taking the time to share such a lo…
User: lauren f
Trip type: Couples
Don’t book
Misleading Room DescriptionWe booked a deluxe room specifically because the hotel's website advertised a balcony with "stunning views" and showed images of glass-fronted balconies overlooking the city. As you can see from the images, this was completely misleading. The balcony was filthy. There was no view at all through the concrete (not glass as shown on the website). Not to mention our room was… Misleading Room DescriptionWe booked a deluxe room specifically because the hotel's website advertised a balcony with "stunning views" and showed images of glass-fronted balconies overlooking the city. As you can see from the images, this was completely mislea…
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